Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN):a first-in-human, open-label intervention study

Background: Perinatal arterial ischaemic stroke (PAIS) is an important cause of neurodevelopmental disabilities. In this first-in-human study, we aimed to assess the feasibility and safety of intranasally delivered bone marrow-derived allogeneic mesenchymal stromal cells (MSCs) to treat PAIS in neonates. Methods: In this open-label intervention study in collaboration with all neonatal intensive care units in the Netherlands, we included neonates born at full term (≥36 weeks of gestation) with MRI-confirmed PAIS in the middle cerebral artery region. All eligible patients were transferred to the... Mehr ...

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Verfasser: Baak, Lisanne M.
Wagenaar, Nienke
van der Aa, Niek E.
Groenendaal, Floris
Dudink, Jeroen
Tataranno, Maria Luisa
Mahamuud, Ubah
Verhage, Cornelia H.
Eijsermans, Rian M.J.C.
Smit, Liesbeth S.
Jellema, Reint K.
de Haan, Timo R.
ter Horst, Hendrik J.
de Boode, Willem P.
Steggerda, Sylke J.
Prins, Henk Jan
de Haar, Colin G.
de Vries, Linda S.
van Bel, Frank
Heijnen, Cobi J.
Nijboer, Cora H.
Benders, Manon J.N.L.
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Reihe/Periodikum: Baak , L M , Wagenaar , N , van der Aa , N E , Groenendaal , F , Dudink , J , Tataranno , M L , Mahamuud , U , Verhage , C H , Eijsermans , R M J C , Smit , L S , Jellema , R K , de Haan , T R , ter Horst , H J , de Boode , W P , Steggerda , S J , Prins , H J , de Haar , C G , de Vries , L S , van Bel , F , Heijnen , C J , Nijboer , C H & Benders , M J N L 2022 , ' Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN) : a first-in-human, open-label intervention study ' , The Lancet Neurology , vol. 21 , no. 6 , pp. 528-536 . https://doi.org/10.1016/S1474-4422(22)00117-X
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27600928
Datenquelle: BASE; Originalkatalog
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Link(s) : https://hdl.handle.net/11370/6d38af5c-25f1-4447-8700-cdcac0831511