The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population
Objectives . A missense SNP, C1858T, in PTPN22 has been identified as a genetic risk factor for rheumatoid arthritis (RA). Subsequent work has suggested that other variants in this gene, in particular a haplotype marked by the minor allele of rs3789604, are associated with RA in white North Americans independent of C1858T. We tested this hypothesis in an independent white Dutch study. Methods. A total of 667 RA patients and 286 controls were genotyped for 13 PTPN22 single nucleotide polymorphisms (SNPs) by allele-specific kinetic polymerase chain reaction. rs3789604 was genotyped in an additio... Mehr ...
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Dokumenttyp: | TEXT |
Erscheinungsdatum: | 2007 |
Verlag/Hrsg.: |
Oxford University Press
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Schlagwörter: | BASIC SCIENCE |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27412372 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://rheumatology.oxfordjournals.org/cgi/content/short/46/4/617 |