Non-myeloablative allogeneic hematopoietic cell transplantation following fludarabine plus 2 Gy TBI or ATG plus 8 Gy TLI: a phase II randomized study from the Belgian Hematological Society
Background: Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). Methods: Here, we report the results of a phase II multicenter randomized study comparing non-myeloablative allo-HCT from HLA-identical siblings (n = 54) or from 10/10 HLA-matched unrelated donors (n = 40) with either fludarabine plus 2 Gy total body irradiation (Flu-TBI arm; n = 49) or 8 Gy TLI + anti-thymocyte globulin (TLI-ATG arm; n = 45) conditioning. Results: The 180-day cumulative incidences of grade II-IV acute GVHD... Mehr ...
Verfasser: |
Baron, Frederic
Zachee, Pierre
Maertens, Johan
Kerre, Tessa
Ory, Aurelie
Seidel, Laurence
Graux, Carlos
Lewalle, Philippe
Van Gelder, Michel
Theunissen, Koen
Willems, Evelyne
Emonds, Marie-Paule
De Becker, Ann
Beguin, Yves |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2015 |
Reihe/Periodikum: |
Baron , F , Zachee , P , Maertens , J , Kerre , T , Ory , A , Seidel , L , Graux , C , Lewalle , P , Van Gelder , M , Theunissen , K , Willems , E , Emonds , M-P , De Becker , A & Beguin , Y 2015 , ' Non-myeloablative allogeneic hematopoietic cell transplantation following fludarabine plus 2 Gy TBI or ATG plus 8 Gy TLI: a phase II randomized study from the Belgian Hematological Society ' , Journal of Hematology & Oncology , vol. 8 , 4 . https://doi.org/10.1186/s13045-014-0098-9 |
Schlagwörter: |
allo-HCT
/ Non-myeloablative conditioning
/ TBI
/ TLI
/ ATG
/ GVHD
/ Graft-versus-leukemia effects |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27301073 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://cris.maastrichtuniversity.nl/en/publications/767795bd-6b8e-4596-8c3e-717daa13874f |