Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa
Carminic acid, a glucosylated anthraquinone found in scale insects like Dactylopius coccus, has since ancient times been used as a red colorant in various applications. Here we show that a membrane-bound C-glucosyltransferase, isolated from D. coccus and designated DcUGT2, catalyzes the glucosylation of flavokermesic acid and kermesic acid into their respective C-glucosides dcII and carminic acid. DcUGT2 is predicted to be a type I integral endoplasmic reticulum (ER) membrane protein, containing a cleavable N-terminal signal peptide and a C-terminal transmembrane helix that anchors the protein... Mehr ...
Verfasser: |
Kannangara, Rubini
Siukstaite, Lina
Borch-Jensen, Jonas
Madsen, Bjorn
Kongstad, Kenneth T.
Stærk, Dan
Bennedsen, Mads
Okkels, Finn T.
Rasmussen, Silas Anselm
Larsen, Thomas Ostenfeld
Frandsen, Rasmus John Normand
Møller, Birger Lindberg |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2017 |
Reihe/Periodikum: |
Kannangara , R , Siukstaite , L , Borch-Jensen , J , Madsen , B , Kongstad , K T , Stærk , D , Bennedsen , M , Okkels , F T , Rasmussen , S A , Larsen , T O , Frandsen , R J N & Møller , B L 2017 , ' Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa ' , Nature Communications , vol. 8 , no. 1 , 1987 . https://doi.org/10.1038/s41467-017-02031-z |
Schlagwörter: |
Journal Article
/ MULTIDISCIPLINARY
/ UDP-GLUCURONOSYLTRANSFERASE UGT1A6
/ PERFORMANCE LIQUID-CHROMATOGRAPHY
/ ENDOPLASMIC-RETICULUM
/ PEDERIN BIOSYNTHESIS
/ PAEDERUS-SABAEUS
/ SIGNAL SEQUENCE
/ COCHINEAL DYE
/ IDENTIFICATION
/ HEMOCYTES
/ CHEMISTRY |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27249788 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://orbit.dtu.dk/en/publications/85b93fee-7364-4889-ac44-8d9c32489f14 |