Background: Amyloid pathology is the pathological hallmark in Alzheimer's disease (AD) and can precede clinical dementia by decades. So far it remains unclear how amyloid pathology leads to cognitive impairment and dementia. To design AD prevention trials it is key to include cognitively normal subjects at high risk for amyloid pathology and to find predictors of cognitive decline in these subjects. These goals can be accomplished by targeting twins, with additional benefits to identify genetic and environmental pathways for amyloid pathology, other AD biomarkers, and cognitive decline. Method... Mehr ...
| Verfasser: |
Konijnenberg, Elles
Carter, Stephen F.
Ten Kate, Mara
Den Braber, Anouk
Tomassen, Jori
Amadi, Chinenye
Wesselman, Linda
Nguyen, Hoang Ton
Van De Kreeke, Jacoba A.
Yaqub, Maqsood
Demuru, Matteo
Mulder, Sandra D.
Hillebrand, Arjan
Bouwman, Femke H.
Teunissen, Charlotte E.
Serné, Erik H.
Moll, Annette C.
Verbraak, Frank D.
Hinz, Rainer
Pendleton, Neil
Lammertsma, Adriaan A.
Van Berckel, Bart N.M.
Barkhof, Frederik
Boomsma, Dorret I.
Scheltens, Philip
Herholz, Karl
Visser, Pieter Jelle |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2018 |
| Reihe/Periodikum: |
Konijnenberg , E , Carter , S F , Ten Kate , M , Den Braber , A , Tomassen , J , Amadi , C , Wesselman , L , Nguyen , H T , Van De Kreeke , J A , Yaqub , M , Demuru , M , Mulder , S D , Hillebrand , A , Bouwman , F H , Teunissen , C E , Serné , E H , Moll , A C , Verbraak , F D , Hinz , R , Pendleton , N , Lammertsma , A A , Van Berckel , B N M , Barkhof , F , Boomsma , D I , Scheltens , P , Herholz , K & Visser , P J 2018 , ' The EMIF-AD PreclinAD study : Study design and baseline cohort overview ' , Alzheimer's Research and Therapy , vol. 10 , 75 , pp. 1-12 . https://doi.org/10.1186/s13195-018-0406-7 |
| Schlagwörter: |
Amyloid
/ Cognitively normal
/ Monozygotic twins
/ Preclinical Alzheimer's disease
/ [F]flutemetamol
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27231670 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/cb252acc-8452-464f-a66e-a3e5202f7e66 |
