Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with sequence variants in nicotine acetylcholine receptor genes and at other loci. To search for additional loci, we conducted a genome-wide association study (GWAS) meta-analysis of nicotine dependence, totaling 38,602 smokers (28,677 Europeans/European Americans and 9925 African Americans) across 15 studies. In this largest-ever GWAS meta-analysis for nicotine dependence and the largest-ever c... Mehr ...
| Verfasser: |
Hancock, D. B.
Guo, Y.
Reginsson, G. W.
Gaddis, N. C.
Lutz, S. M.
Sherva, R.
Loukola, A.
Minica, C. C.
Markunas, C. A.
Han, Y.
Young, K. A.
Gudbjartsson, D. F.
Gu, F.
McNeil, D. W.
Qaiser, B.
Glasheen, C.
Olson, S.
Landi, M. T.
Madden, P. A.F.
Farrer, L. A.
Vink, J.
Saccone, N. L.
Neale, M. C.
Kranzler, H. R.
McKay, J.
Hung, R. J.
Amos, C. I.
Marazita, M. L.
Boomsma, D. I.
Baker, T. B.
Gelernter, J.
Kaprio, J.
Caporaso, N. E.
Thorgeirsson, T. E.
Hokanson, J. E.
Bierut, L. J.
Stefansson, K.
Johnson, E. O. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2018 |
| Reihe/Periodikum: |
Hancock , D B , Guo , Y , Reginsson , G W , Gaddis , N C , Lutz , S M , Sherva , R , Loukola , A , Minica , C C , Markunas , C A , Han , Y , Young , K A , Gudbjartsson , D F , Gu , F , McNeil , D W , Qaiser , B , Glasheen , C , Olson , S , Landi , M T , Madden , P A F , Farrer , L A , Vink , J , Saccone , N L , Neale , M C , Kranzler , H R , McKay , J , Hung , R J , Amos , C I , Marazita , M L , Boomsma , D I , Baker , T B , Gelernter , J , Kaprio , J , Caporaso , N E , Thorgeirsson , T E , Hokanson , J E , Bierut , L J , Stefansson , K & Johnson , E O 2018 , ' Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence ' , Molecular Psychiatry , vol. 23 , no. 9 , pp. 1911–1919 . https://doi.org/10.1038/mp.2017.193 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27231277 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/74b77807-4971-4bf7-99f1-e9947f82780b |
