Many but small hiv-1 non-b transmission chains in the netherlands
Objective:The aim of this study was to investigate introductions and spread of different HIV-1 subtypes in the Netherlands.Design:We identified distinct HIV-1 transmission chains in the Netherlands within the global epidemic context through viral phylogenetic analysis of partial HIV-1 polymerase sequences from individuals enrolled in the ATHENA national HIV cohort of all persons in care since 1996, and publicly available international background sequences.Methods:Viral lineages circulating in the Netherlands were identified through maximum parsimony phylogeographic analysis. The proportion of... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2022 |
Reihe/Periodikum: | Bezemer , D , Blenkinsop , A , Hall , M , Van Sighem , A , Cornelissen , M , Wessels , E , Van Kampen , J , Van De Laar , T , Reiss , P , Fraser , C & Ratmann , O 2022 , ' Many but small hiv-1 non-b transmission chains in the netherlands ' , AIDS , vol. 36 , no. 1 , pp. 83-94 . https://doi.org/10.1097/QAD.0000000000003074 |
Schlagwörter: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / SDG 3 - Good Health and Well-being |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27227058 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://pure.eur.nl/en/publications/bce96c8f-b18b-46ad-95d9-26477364ae82 |
Objective:The aim of this study was to investigate introductions and spread of different HIV-1 subtypes in the Netherlands.Design:We identified distinct HIV-1 transmission chains in the Netherlands within the global epidemic context through viral phylogenetic analysis of partial HIV-1 polymerase sequences from individuals enrolled in the ATHENA national HIV cohort of all persons in care since 1996, and publicly available international background sequences.Methods:Viral lineages circulating in the Netherlands were identified through maximum parsimony phylogeographic analysis. The proportion of HIV-1 infections acquired in-country among heterosexuals and MSM was estimated from phylogenetically observed, national transmission chains using a branching process model that accounts for incomplete sampling.Results:As of 1 January 2019, 2589 (24%) of 10 971 (41%) HIV-1 sequenced individuals in ATHENA had non-B subtypes (A1, C, D, F, G) or circulating recombinant forms (CRF01AE, CRF02AG, CRF06-cpx). The 1588 heterosexuals were in 1224, and 536 MSM in 270 phylogenetically observed transmission chains. After adjustments for incomplete sampling, most heterosexual (75%) and MSM (76%) transmission chains were estimated to include only the individual introducing the virus (size = 1). Onward transmission occurred mostly in chains size 2-5 amongst heterosexuals (62%) and in chains size at least 10 amongst MSM (64%). Considering some chains originated in-country from other risk-groups, 40% (95% confidence interval: 36-44) of non-B-infected heterosexuals and 62% (95% confidence interval: 49-73) of MSM-acquired infection in-country.Conclusion:Although most HIV-1 non-B introductions showed no or very little onward transmission, a considerable proportion of non-B infections amongst both heterosexuals and MSM in the Netherlands have been acquired in-country.