Parental lifespan and the likelihood of reaching the age of 90 years in the Netherlands Cohort Study
Aim: Growing evidence suggests an association between parental longevity and lifespan of subsequent generations. We aimed to reproduce earlier findings, showing a positive association between parental longevity and offspring's longevity. Additionally, we investigated whether this is mainly driven by the maternal or paternal germline in male and female offspring. Methods: For these analyses, data from the oldest birth cohort (1916-17) of the Netherlands Cohort Study was used. Participants filled in a baseline questionnaire in 1986 (at age 68-70 years). Follow up for vital status information unt... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2021 |
Reihe/Periodikum: | Brandts , L , van Poppel , F W A & van den Brandt , P A 2021 , ' Parental lifespan and the likelihood of reaching the age of 90 years in the Netherlands Cohort Study ' , Geriatrics & Gerontology International , vol. 21 , no. 2 , pp. 215-221 . https://doi.org/10.1111/ggi.14120 |
Schlagwörter: | aging / cohort study / longevity / parental lifespan / survival / GENOME-WIDE ASSOCIATION |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27207133 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://cris.maastrichtuniversity.nl/en/publications/ffadebfe-b598-47fe-888c-9e07fec96125 |
Aim: Growing evidence suggests an association between parental longevity and lifespan of subsequent generations. We aimed to reproduce earlier findings, showing a positive association between parental longevity and offspring's longevity. Additionally, we investigated whether this is mainly driven by the maternal or paternal germline in male and female offspring. Methods: For these analyses, data from the oldest birth cohort (1916-17) of the Netherlands Cohort Study was used. Participants filled in a baseline questionnaire in 1986 (at age 68-70 years). Follow up for vital status information until the age of 90 years (2006-07) was >99.9% complete. Multivariable-adjusted Cox regression analyses with a fixed follow-up time were based on 2368 men and 2657 women with complete parental survival data and relevant confounders to calculate risk ratios (RR) of reaching longevity. Results: In age-adjusted models, paternal and maternal age at death were significantly positively associated with reaching 90 years in both male and female offspring. In male offspring, paternal age at death (>= 90 years vs = 90 years vs Discussion: After confounder adjustment, stronger and significant associations were observed between paternal lifespan and male offspring longevity, and maternal lifespan and female offspring longevity. Future research should investigate through which pathways a longer lifespan of parents is transmitted to their offspring.