SHV-14, a Novel β-Lactamase Variant in Klebsiella pneumoniae Isolates from Nijmegen, The Netherlands
ABSTRACT Four ceftazidime-resistant isolates of a Klebsiella pneumoniae strain were collected from intensive care unit patients in Nijmegen, The Netherlands. These isolates had TEM-29 and SHV-14 β-lactamases. SHV-14 is a novel variant, with two substitutions compared with the sequence of SHV-1: Ile8Phe and Arg43Ser. Its gene also had a silent C→T mutation at nucleotide 481. The SHV-14 enzyme had slightly higher V max rates than SHV-1 for oxyimino-aminothiazolyl cephalosporins, but this activity was insufficient for the enzyme to count as an extended-spectrum β-lactamase.
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2001 |
Reihe/Periodikum: | Antimicrobial Agents and Chemotherapy ; volume 45, issue 1, page 309-311 ; ISSN 0066-4804 1098-6596 |
Verlag/Hrsg.: |
American Society for Microbiology
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Schlagwörter: | Infectious Diseases / Pharmacology (medical) / Pharmacology |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27177907 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1128/aac.45.1.309-311.2001 |