EORTC-1203-GITCG - the "INNOVATION"-trial: Effect of chemotherapy alone versus chemotherapy plus trastuzumab, versus chemotherapy plus trastuzumab plus pertuzumab, in the perioperative treatment of HER2 positive, gastric and gastroesophageal junction adenocarcinoma on pathologic response rate: a randomized phase II-intergroup trial of the EORTC-Gastrointestinal Tract Cancer Group, Korean Cancer Study Group and Dutch Upper GI-Cancer group.
10-20% of patients with gastric cancer (GC) have HER2+ tumors. Addition of trastuzumab (T) to cisplatin/fluoropyrimidine-based chemotherapy (CT) improved survival in metastatic, HER2+ GC. When pertuzumab (P) was added to neoadjuvant T and CT, a significant increase in histopathological complete response rate was observed in HER2+ breast cancer. This study aims to investigate the added benefit of using both HER2 targeting drugs (T alone or the combination of T + P), in combination with perioperative CT for localized HER2+ GC. This is a prospective, randomized, open-label, phase II trial. HER2 s... Mehr ...
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Dokumenttyp: | review |
Erscheinungsdatum: | 2019 |
Schlagwörter: | Gastric cancer / Gastro-esophageal junction cancer / HER2 / Perioperative chemotherapy / Pertuzumab / Trastuzumab |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27063680 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://serval.unil.ch/notice/serval:BIB_7D31BF0D4734 |