Abstract: 1Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium; Department of Anesthesiology, UZLeuven, Leuven, Belgium & Department of Cardiovascular Sciences, KULeuven, Leuven, Belgium; Department of Anesthesiology, OLV Hospital, Aalst, Belgium; 2Department of Electronics and Information Systems, IBiTech, Ghent University, Ghent, Belgium; Department of Anesthesia and Critical Care, AZ Sint-Jan Brugge Oostende, Bruges, Belgium; 3Department of Anesthesia and Intensive Care Medicine, Liege University Hospital, Liege, Belgium; Anesthesia and Perioperative Neuroscience Laboratory, GIGA-Consciousness Thematic Unit, GIGA- Research, Liege University, Liege, Belgium; 4Department of Anesthesiology and Perioperative Medicine, Ghent University Hospital, Ghent, Belgium; Department of Basic and Applied Medical Sciences Ghent University, Ghent, Belgium; 5Department of Anesthesia and Intensive Care Medicine, Liege University Hospital, Liege, Belgium; 6Department of Anesthesiology, OLV Hospital, Aalst, Belgium. Department of Basic and Applied Medical Sciences Ghent University, Ghent, Belgium; 7Department of Anesthesiology, University Hospital Antwerp, Antwerp, Belgium; 8Department of Anesthesiology and Pain Medicine, Saint-Pierre University Hospital, Universite Libre de Bruxelles (ULB), Brussels, Belgium; 9Department of Anesthesiology, Cliniques universitaires Saint-Luc; Universite catholique de Louvain (UCLouvain), Brussels, Belgium; 10Department of Anesthesiology, University Hospitals Leuven; Department of Cardiovascular Sciences, KU Leuven; 11Department of Anesthesiology and perioperative medicine, University Hospital Brussels (UZ Brussesl), Brussels, Belgium; 12Department of Anesthesiology, Hopital Universitaire de Bruxelles - Hopital Erasme, Brussels, Belgium. Universite Libre de Bruxelles, Brussels, Belgium.