Phenotypic screening of cannabinoid receptor 2 ligands shows different sensitivity to genotype
The Cannabinoid Receptor 2 (CB2R) is a G protein-coupled receptor (GPCR) investigated intensively as therapeutic target, however no drug has reached the market yet. We investigated personal differences in CB2R drug responses using a label-free whole-cell assay (xCELLigence) combined with cell lines (Lymphoblastoid Cell Lines) from individuals with varying CB2R genotypes. Responses to agonists, partial agonists and antagonists of various chemical classes were characterized. Endogenous cannabinoids such as 2-AG induced cellular effects vastly different from all synthetic cannabinoids, especially... Mehr ...
Verfasser: |
Hillger, Julia M
le Roy, Beau
Wang, Zi
Mulder-Krieger, Thea
Boomsma, Dorret I
Slagboom, P. Eline
Danen, Erik H J
IJzerman, Adriaan P
Heitman, Laura H |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2017 |
Reihe/Periodikum: |
Hillger , J M , le Roy , B , Wang , Z , Mulder-Krieger , T , Boomsma , D I , Slagboom , P E , Danen , E H J , IJzerman , A P & Heitman , L H 2017 , ' Phenotypic screening of cannabinoid receptor 2 ligands shows different sensitivity to genotype ' , Biochemical Pharmacology , vol. 130 , pp. 60-70 . https://doi.org/10.1016/j.bcp.2017.01.014 |
Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26845416 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/eed7d277-4029-4d14-bb7e-0dfe79fcdf78 |