Personality traits are complex phenotypes related to psychosomatic health. Individually, various gene finding methods have not achieved much success in finding genetic variants associated with personality traits. We performed a meta-analysis of four genome-wide linkage scans (N=6149 subjects) of five basic personality traits assessed with the NEO Five-Factor Inventory. We compared the significant regions from the meta-analysis of linkage scans with the results of a meta-analysis of genome-wide association studies (GWAS) (N∼17 000). We found significant evidence of linkage of neuroticism to chr... Mehr ...
| Verfasser: |
Amin, N.
Hottenga, J.J.
Hansell, N.K.
Janssens, A.C.J.W.
de Moor, M.H.M.
Madden, P.A.F.
Zorkoltseva, I.V.
Penninx, B.W.J.H.
Terracciano, A.
Uda, M.
Tanaka, T.
Esko, T.
Realo, A.
Ferrucci, L.
Luciano, M
Davies, G.
Metspalu, A.
Abecasis, G.R.
Deary, I.J.
Raikkonen, K.
Bierut, L.J.
Costa, P.T.
Savyuk, V.
Zhu, G.
Kirichenko, A.V.
Isaacs, A.
Aulchenko, Y.S.
Willemsen, G.
Heath, A.C.
Pergadia, M.L.
Medland, S.E.
Axenovich, T.I.
de Geus, E.J.C.
Montgomery, G.W.
Wright, M.J.
Oostra, B.A.
Martin, N.G.
Boomsma, D.I.
van Duijn, C.M. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2013 |
| Reihe/Periodikum: |
Amin , N , Hottenga , J J , Hansell , N K , Janssens , A C J W , de Moor , M H M , Madden , P A F , Zorkoltseva , I V , Penninx , B W J H , Terracciano , A , Uda , M , Tanaka , T , Esko , T , Realo , A , Ferrucci , L , Luciano , M , Davies , G , Metspalu , A , Abecasis , G R , Deary , I J , Raikkonen , K , Bierut , L J , Costa , P T , Savyuk , V , Zhu , G , Kirichenko , A V , Isaacs , A , Aulchenko , Y S , Willemsen , G , Heath , A C , Pergadia , M L , Medland , S E , Axenovich , T I , de Geus , E J C , Montgomery , G W , Wright , M J , Oostra , B A , Martin , N G , Boomsma , D I & van Duijn , C M 2013 , ' Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions ' , European Journal of Human Genetics , vol. 21 , no. 8 , pp. 876-882 . https://doi.org/10.1038/ejhg.2012.263 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26845026 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/bed5b505-16d3-4bb5-9a15-c24e4e6b5089 |
