Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10
| Verfasser: |
Bradfield, J.P.
Taal, H.R.
Timpson, N.J.
Scherag, A.
Lecoeur, C.
Warrington, N.M.
Hypponen, E.
Holst, C.
Valcarcel, B.
Thiering, E.
Salem, R.M.
Schumacher, F.R.
Cousminer, D.L.
Sleiman, P.M.A.
Zhao, J.
Berkowitz, R.I.
Vimaleswaran, K.S.
Jarick, I.
Pennell, C.E.
Evans, D.M.
St Pourcain, B.
Berry, D.J.
Mook-Kanamori, D.O.
Hofman, A.
Rivadeneira, F.
Uitterlinden, A.G.
van Duijn, C.M.
van der Valk, R.J.P.
de Jongste, J.C.
Postma, D.S.
Boomsma, D.I.
Gauderman, W.J.
Hassanein, M.T.
Lindgren, C.M.
Mägi, R.
Boreham, C.A.G.
Neville, C.E.
Moreno, L.A.
Elliott, P.
Pouta, A.
Hartikainen, A.-L.
Li, M.
Raitakari, O.
Lehtimäki, T.
Eriksson, J.G.
Palotie, A.
Dallongeville, J.
Das, S.
Deloukas, P.
McMahon, G.
Ring, S.M.
Kemp, J.P.
Buxton, J.L.
Blakemore, A.I.F.
Bustamante, M.
Guxens, M.
Hirschhorn, J.N.
Gillman, M.W.
Kreiner-Møller, E.
Bisgaard, H.
Gilliland, F.D.
Heinrich, J.
Wheeler, E.
Barroso, I.
O'Rahilly, S.
Meirhaeghe, A.
Sørensen, T.I.A.
Power, C.
Palmer, L.J.
Hinney, A.
Widen, E.
Farooqi, I.S.
McCarthy, M.I.
Froguel, P.
Meyre, D.
Hebebrand, J.
Järvelin, M.J.
Jaddoe, V.W.V.
Smith, G.D.
Hakonarson, H.
Grant, S.F.A. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2012 |
| Reihe/Periodikum: |
Bradfield , J P , Taal , H R , Timpson , N J , Scherag , A , Lecoeur , C , Warrington , N M , Hypponen , E , Holst , C , Valcarcel , B , Thiering , E , Salem , R M , Schumacher , F R , Cousminer , D L , Sleiman , P M A , Zhao , J , Berkowitz , R I , Vimaleswaran , K S , Jarick , I , Pennell , C E , Evans , D M , St Pourcain , B , Berry , D J , Mook-Kanamori , D O , Hofman , A , Rivadeneira , F , Uitterlinden , A G , van Duijn , C M , van der Valk , R J P , de Jongste , J C , Postma , D S , Boomsma , D I , Gauderman , W J , Hassanein , M T , Lindgren , C M , Mägi , R , Boreham , C A G , Neville , C E , Moreno , L A , Elliott , P , Pouta , A , Hartikainen , A-L , Li , M , Raitakari , O , Lehtimäki , T , Eriksson , J G , Palotie , A , Dallongeville , J , Das , S , Deloukas , P , McMahon , G , Ring , S M , Kemp , J P , Buxton , J L , Blakemore , A I F , Bustamante , M , Guxens , M , Hirschhorn , J N , Gillman , M W , Kreiner-Møller , E , Bisgaard , H , Gilliland , F D , Heinrich , J , Wheeler , E , Barroso , I , O'Rahilly , S , Meirhaeghe , A , Sørensen , T I A , Power , C , Palmer , L J , Hinney , A , Widen , E , Farooqi , I S , McCarthy , M I , Froguel , P , Meyre , D , Hebebrand , J , Järvelin , M J , Jaddoe , V W V , Smith , G D , Hakonarson , H & Grant , S F A 2012 , ' A genome-wide association meta-analysis identifies new childhood obesity loci ' , Nature Genetics , vol. 44 , no. 5 , pp. 526-532 . https://doi.org/10.1038/ng.2247 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26844985 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/b9d6e27d-f428-4b3a-ba4b-75b67dd1fe23 |
