Influenza-epidemie in een verpleeghuis door een virus dat niet in het vaccin was opgenomen
In the autumn of 1992 two-thirds of the population of a nursing home in Amsterdam was vaccinated against influenza. However, in March 1993 an outbreak of an influenza like illness occurred with a morbidity rate of 49% and a mortality rate of 10%. There was sufficient serological evidence to show that the vaccine as such had induced adequate immunity. As the causative agent an influenza A/H3N2 virus was identified. The failing activity of the vaccine in this instance was apparently caused by the absence of sufficient antigen similarity between the A/H3N2 vaccine component and the epidemic virus... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 1993 |
Schlagwörter: | *Disease Outbreaks / Aged / 80 and over / Antibodies / Viral/isolation & purification / Female / Humans / Influenza A virus/*immunology / Influenza Vaccines/*immunology / Influenza / Human/*epidemiology/mortality / Male / Middle Aged / Netherlands/epidemiology / Nursing Homes |
Sprache: | Niederländisch |
Permalink: | https://search.fid-benelux.de/Record/base-26832404 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://repub.eur.nl/pub/15032 |
In the autumn of 1992 two-thirds of the population of a nursing home in Amsterdam was vaccinated against influenza. However, in March 1993 an outbreak of an influenza like illness occurred with a morbidity rate of 49% and a mortality rate of 10%. There was sufficient serological evidence to show that the vaccine as such had induced adequate immunity. As the causative agent an influenza A/H3N2 virus was identified. The failing activity of the vaccine in this instance was apparently caused by the absence of sufficient antigen similarity between the A/H3N2 vaccine component and the epidemic virus ('vaccine mismatch').