Circulating de novo lipogenesis fatty acids and all-cause mortality in a prospective Dutch population cohort

Background: Circulating fatty acids (FA) from de novo lipogenesis (DNL) are associated with all-cause mortality in individuals with elevated CVD risk. However, compared to FA early in the DNL synthetic pathway, cis-vaccenic acid, one of the FA distal in the DNL synthetic pathway, has rarely been studied in a general population cohort. We hypothesized that circulating cis-vaccenic acid is more strongly related to all-cause mortality than other circulating DNL-related FA. Objectives: The primary and secondary objectives of this study were to investigate the prospective associations of plasma lev... Mehr ...